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Thin Endometrium and Platelet Rich Plasma Therapy
Despite recent developments in assisted reproductive techniques (ART), the implantation rates still remain relatively low. Successful implantation requires high quality embryo and receptive endometrium. The receptive endometrium is defined as a healthy uterine milieu containing the transformation of endometrial cells into decidua cells appropriate for implantation of blastocysts and rapid growth of placenta.
Endometrial assessment is routinely performed during in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Endometrial thickness (EMT) has been considered as a marker of endometrium receptivity and a prognostic factor for embryo transfers during IVF/ICSI treatment. It is known that appropriate endometrial thickness is essential for a successful pregnancy, and several studies have shown low pregnancy rates in the presence of thin endometrium.
The optimal endometrial thickness for conception remains controversial among clinicians. EMT less than 7 mm on ultrasound is generally considered sub-optimal for embryo transfer and is correlated to a decreased probability of pregnancy. Thin endometrium remains a challenge in gynecology and reproductive science, with only slight enhancements attained with the currently available treatment. It is considered that a thin endometrium is caused by a diminished normal endometrial growth. However, little evidence is presented with regard to reasons for impaired endometrial growth in patients with thin endometrium.
Angiogenesis plays a key role in endometrial pattern. Endometrial angiogenesis is vital for regeneration endometrium after menstruation, and to provide a vascularized receptive endometrium for implantation. The majority of studies have focused on vascular endothelial growth factor (VEGF) as a regulator for endometrial angiogenesis, and a number of works state that VEGF is expressed differentially in the uterine with thin endometrium.
Uterine blood flow is an essential marker regulating endometrial growth and is narrowly related to vascular development of the endometrium. Recent improvements in ultrasonography have provided new opportunities for noninvasive evaluation of endometrial perfusion. A significant reduced pregnancy rate in IVF-ET patients with low uterine blood flow displays a close relationship between uterine blood flow and uterine receptivity.
Treatment of thin endometrium
Since a thin endometrium is a multifactorial condition, its management should be cause-related, with the aim of increasing endometrial receptivity and simplifying implantation. However, improving endometrial growth in patients with thin endometrium is very challenging.
Several modes of therapies are used for development of endometrium like estrogens, micronized progesterones, low-dose aspirin, low-dose steroids, and G-CSF granulocyte colony stimulation factor, with variable results. Thin endometrium non-responsive to standard treatments is still a challenge in assisted reproductive techniques, resulting in cycle cancellation and unplanned embryo cryopreservation.
Platelet-rich plasma (PRP)
Platelet-rich plasma seems to be the most interesting and effective therapy for thin endometrium.
PRP is prepared from patient’s own blood and is a concentrate of platelets, which are rich in several growth factors and cytokines. As soon as platelets are activated in PRP, cytokines and growth factors are secreted within 10 minutes.
Recently, PRP has been commonly applied in different clinical situations; however, little is identified about the application of PRP in the treatment of thin endometrium. For the first time, Chang and coworkers introduced intrauterine infusion of PRP as a new approach for the treatment of thin endometrium. They evaluated the efficacy of PRP in the therapy of infertile women with thin endometrium. Five women with thin endometrium after standard hormone replacement therapy (HRT) who were candidate for IVF were included the study. PRP was infused into the uterine cavity on the 10th day of HRT cycle. If endometrial thickness failed to improve 72 h later, PRP infusion was done 1–2 times in each cycle. Embryos were transferred when the endometrium thickness reached more than 7 mm. Endometrial growth, as well as successful pregnancy, occurred in all the patients after PRP infusion.
In the same way, 10 patients with a history of inadequate endometrial growth in FET cycles were enrolled in another study. Intrauterine infusion of PRP was performed for all patients. According to the results, endometrial thickness increased, and 50% of patients achieved pregnancy. With the promise of providing a battery of growth factors and proven effect in rejuvenation, repair, and restoration, PRP therapy is emerging as an important modality for treatment of thin endometrium. Preparation of PRP for thin endometrial treatment is different than for other therapies.
PRP Therapy for Male Sexual Dysfunction
Male sexual dysfunction can be more than just erectile dysfunction, although this is the most common occurrence of sexual dysfunction in men. With plenty of pharmaceuticals available designed to temporarily relieve erectile dysfunction, men are looking for a more natural and permanent treatment for erectile dysfunction and sexual dysfunction that does not require them to “schedule” sexual encounters around taking a pill.
Penile platelet-rich plasma for male sexual dysfunction is revolutionizing the expectations of men suffering with the symptoms of sexual dysfunction and erectile dysfunction. Although the causes of male sexual dysfunction vary greatly, from illness and obesity to injuries, psychological disorders, and more, PRP Injections for male sexual dysfunction applied directly to the male genitals has given outstanding results in stimulating sexual function and helping patients overcome symptoms of sexual dysfunction.
If you are looking to avoid the dizzying lists of side-effects printed in microscopic size on the packaging of all the popular erectile dysfunction pharmaceuticals and want to reclaim your sexual satisfaction without being bound to the schedule of your medication, talk to a local penile platelet-rich plasma doctor about PRP injections for male sexual dysfunction today. A simple yet revolutionary outpatient procedure can help your body naturally restore optimal sexual function and put you back in the driver’s seat of your love life.
How can Platelet-Rich Plasma (PRP) Treat Erectile Dysfunction?
The Priapus Shot, a revolutionary new procedure from the creators of the popular Vampire Facelift, can treat erectile dysfunction using platelet-rich plasma (PRP). The Priapus Shot procedure is non-invasive and doesn’t carry the heart-health risks that many traditional erectile dysfunction treatments do.
The Priapus Shot uses natural, regenerative cells that are drawn from your bloodstream. These cells are refined to just the platelet-rich plasma (PRP), using a highly-advanced centrifuge.
By administering platelet-rich plasma directly to the penis, the Priapus Shot (also called the M-Shot) delivers erections that are:
• Firmer
• Larger
• More frequent
• Longer-lasting
1. Fat transfer and platelet-rich plasma for breast lift Fat transfer is the process of taking unwanted body fat (liposuction procedure) from other parts of the body and processing it before injecting it to upper part of the breast and in the cleavage area. This is immediate enhancement. And, since it’s immediate, the sudden expansion of the breast can cause blood vessels to be blocked, causing some parts of the breasts or the nipples to lose sensitivity. Sometimes, it can even cause the skin in those areas to go haywire. So, the best way to avoid that is to make sure enough collagen and growth factors are supplied, well in excess of the area’s needs. That’s why it makes sense to combine the fat transfer procedure with platelet-rich plasma. In this combination, PRP is added to the fat when processing the fat, which includes many blood-derived growth factors and tissues containing collagen for skin rejuvenation. The end-product is then injected like a typical PRP injection. The result is firmer breasts with not just a change in size, but also changes in skin texture and shape of the breast. And there’s no worry of losing sensitivity. Some call the entire procedure as Platelet-Rich Plasma Facelift. Results generally last from 9-18 months. This great procedure has boosted the confidence level of thousands of women who wanted to overcome their unnatural shaping and aging of breasts. However, even though it works for all kind of breast sizes, it’s not recommended for women with: • Extreme loss of volume • Excessive sagging • Previous breast implants 2. Only platelet rich plasma for breast rejuvenation This second procedure is purely PRP for rejuvenation purposes. It’s for women who’re happy with their breast size, but would love to rejuvenate the skin for youthful look, restore fullness for healthy breasts, and regain sensitivity in areas where it’s diminished. The procedure is same as any other platelet-rich plasma procedure. PRP injection not only enhances the look, it actually produces new tissues in the area because of all those growth factors, resulting in better cleavage and fullness.
