Pharma

The Thalidomide Tragedy and its Effect on Drug Safety Regulations

Swiss pharmaceutical company Ciba first synthesized thalidomide, a sedative similar to barbiturates, in 1953. The company’s intention was to use it as an anticonvulsant; however, since no such success was seen in tested lab animals, the company stopped its research on the drug. In October 1957, West German company Chemie …

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Antimicrobial Stewardship Program at Karuna Hospital

The more we use antibiotics, the more we lose antibiotics.   A young male patient with diagnosis of sepsis secondary to pneumonia was referred to us from another hospital. On reviewing his lab investigation reports, microbial culture reports of sputum, blood, and urine were missing. Chest X ray of the …

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Favipiravir: Deciphering in COVID-19

The pandemic outbreak of coronavirus COVID-19 that started in China in late December 2019 is a severe acute respiratory syndrome (SARS- CoV-2) and has now walloped the world. COVID-19 has led to unprecedented challenges with devastating health and socio-economic impacts. Scientists and researchers are striving to contain the coronavirus with …

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Pharma Marketing: Need for Change in Modus Operandi

The “covilution” (covid induced revolution) change is occurring in most industries, and more importantly, consumer behavior, globally. In the pharma industry, traditional pharma marketing methods are now becoming mostly dysfunctional and ineffective. Pharma marketing leaders are still confused and not very clear about how to respond to the changed situation. …

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Now, Moderna!

After US manufacturer Pfizer’s 90% effectiveness claim of its COVID-19 vaccine, and Russia’s Sputnik V’s claim of 92% effectiveness, now, US company Moderna is saying that its vaccine is 94.5% effective against the virus that has turned the world upside down. Wonder who’s going to be the first to claim …

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Turkish Airlines : Guidelines for Safe Travel

Turkish Airlines has started its operations worldwide and is proud to welcome its passengers to Turkey and beyond destinations with all health and international safety protocols. Turkish Airlines in Kathmandu currently operates 3 weekly flights to and from Istanbul and beyond. Globally, the airlines has started operating to over 206 …

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EMA Endorses Dexamthasone for COVID-19

After reviewing the results of the RECOVERY study arm involving use of dexamethasone in the treatment of hospitalized COVID-19 patients, the European Medicines Agency (EMA) has concluded that dexamethasone can be considered a treatment option for patients requiring oxygen therapy (from supplemental oxygen to mechanical ventilation). EMA is endorsing the …

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U.S. FDA approves Remdesivir for COVID-19

Even though the World Health Organization has published the largest randomized trial showing that remdesivir showed no benefit on reducing hospital stays or mortality, the drug has been approved by the U.S. FDA for standard of care use for hospitalized COVID-19 patients. The approval was based on a study by …

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Roche /Atea Pharmaceuticals collaborate to develop oral COVID-19 treatment

Roche and Atea Pharmaceutical are collaborating to develop, manufacture, and distribute Atea’s investigational oral direct-acting antiviral AT-527, which acts by blocking the viral RNA polymerase enzyme needed for viral replication. It is currently undergoing phase 2 clinical trial for hospitalized patients with moderate COVID-19, with phase 3 clinical trial expected …

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